Dissolution Calculator
Accelerate your dissolution analysis with confidence. This smart, HPLC-based calculator simplifies complex calculations, reduces human error, and ensures precise drug release results—every time
Dissolution Calculator (HPLC)
What Is Dissolution Testing?
- Dissolution is the process by which a drug releases its active pharmaceutical ingredient (API) into solution, typically in a simulated physiological environment.
- It is a critical quality control (QC) and development tool to evaluate drug product performance, bioavailability, and consistency.
Scientific Basis for Calculation
Components Explained:
| Field Name on Calculator | Scientific Term | Description |
|---|---|---|
| Sample Peak Area (As) | As | Area of the analyte peak from the sample injection |
| Standard Peak Area (Ast) | Ast | Area of the analyte peak from the standard injection |
| Sample Aliquot Volume (Vs) | Vs | Volume taken from the sample solution for dilution |
| Sample Total Dilution Volume (Vts) | Vts | Final volume after diluting the sample |
| Standard Aliquot Volume (Vst) | Vst | Volume taken from the standard solution |
| Standard Total Dilution Volume (Vtst) | Vtst | Final volume after diluting the standard |
| Standard Stock Concentration (Cst) [mg/mL] | Cst | Known concentration of the standard stock solution |
| Volume of Dissolution Medium (V) [mL] | V | Total dissolution volume used during the test (e.g., 900 mL) |
| Label Claim (L) [mg] | L | Theoretical amount of drug expected per dosage unit |
| Standard Purity (Pst) [%] | Pst | Purity of the standard used, enter as % (default 100%) |
Scientific Notes & Tips for This Calculator
- ✅ Handles Multiple Dilutions – Both sample and standard dilution steps are built in (Vst/Vtst and Vs/Vts).
- ✅ Purity Correction – Accounts for less-than-100% pure reference standard.
- ✅ Versatile for QC & R&D – Can be used for routine testing or method validation batches.
- ✅ Applicable for USP/ICH Methods – Aligned with standard dissolution practices per USP <711> and ICH Q6A.